{"id":1215,"date":"2022-11-18T12:15:13","date_gmt":"2022-11-18T12:15:13","guid":{"rendered":"https:\/\/www.rumexperts.vet\/?post_type=training&p=1215"},"modified":"2024-03-19T15:59:06","modified_gmt":"2024-03-19T14:59:06","slug":"public-pas-ce-soir-jai-mal-a-la-tete-prend-une-une-aspirine","status":"publish","type":"training","link":"https:\/\/www.rumexperts.vet\/en\/training\/public-pas-ce-soir-jai-mal-a-la-tete-prend-une-une-aspirine","title":{"rendered":"Public – NOT TONIGHT I HAVE A HEADACHE: TAKE AN ASPIRIN"},"content":{"rendered":"

REFERENCE : Barragan AA et al. Effects of postpartum acetylsalicylic acid on metabolic status, health, and production in lactating dairy cattle. J.Dairy Sci 2020, 103 https:\/\/doi.org\/10.3168\/jds.2019-17966<\/a>.<\/p>\n

BACKGROUND<\/span><\/h3>\n

Calving is a real challenge for a cow. Acetonemia and hypocalcemia are present. These metabolic pathologies will reduce the immune defense capacities and thus expose the animal to uterine or mammary infections.<\/p>\n

Reducing inflammation would seem to be a strategy for preventing postpartum pathologies. Except that inflammation can be necessary, the expulsion of the placenta is an example. The use of meglumine flunixin, a non-steroidal anti-inflammatory drug (NSAID) increases the incidence of placental retention.<\/p>\n

The use of acetylsalicylic acid (ASA, i.e., aspirin) administered by injection or intravenously for 2 to 7 days helps to increase milk production and, according to some authors, to reduce the concentration of haptoglobin, a marker of inflammation.<\/p>\n

The authors of this study propose to study the effects of a double administration of ASA on milk production, inflammation and postpartum pathologies.<\/p>\n

The study involved 74 primiparous and 157 pluriparous Holsteins producing an average of 11,1543 kg of milk per year (3 daily milkings and total mixed ration).<\/p>\n

The treatment consisted of 4 doses of 200 mg\/kg of ASA administered per os (lance bolus) at 12 hour intervals, the first dose being administered 12 hours after parturition.<\/p>\n

THEIR OBSERVATIONS<\/span><\/h3>\n
    \n
  • Pluriparous cows produced 1.64 kg more milk per day (41.6 vs 40.0 kg\/d: P<0.04).<\/li>\n
  • The treatment had no effect on the milk production of primiparous cows (30.9 vs 31.5 kg\/d).<\/li>\n
  • Treatment had no effect on total useful matter, fat or protein in 305 days.<\/li>\n
  • Treatment was accompanied by a lower BHB concentration (0.99 mmol\/L vs 1 .16 mmol\/L: P < 0.02).<\/li>\n
  • Treatment had no significant effect on haptoglobin concentration assessed 7 (234 \u00b1 66.71 \u00b5g\/mL vs 211 \u00b1 62.87 \u00b5g\/mL in untreated cows) or 30 hours (159 \u00b1 37.79 \u00b5g\/mL vs 173 \u00b1 42.66 \u00b5g\/mL in untreated cows) after calving.<\/li>\n
  • Treatment had no effect on rumination, frequency of hyperthermia (> 39.5\u00b0C), dystocia, milk conductivity, retained placenta, milk fever, displaced abomasum, acetonemia, metritis, mastitis, pneumonia, lameness, or digestive problem.<\/li>\n<\/ul>\n

    MORALITY<\/span><\/h3>\n

    Does the benefit offset the cost of the extra work involved in this preventive treatment ?<\/h3>\n<\/div>
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