{"id":1409,"date":"2023-02-06T10:00:24","date_gmt":"2023-02-06T09:00:24","guid":{"rendered":"https:\/\/www.rumexperts.vet\/?post_type=training&#038;p=1409"},"modified":"2024-03-19T08:25:10","modified_gmt":"2024-03-19T07:25:10","slug":"public-250-%ce%bcg-dune-gonadoreline-et-10-de-gestation-en-plus","status":"publish","type":"training","link":"https:\/\/www.rumexperts.vet\/en\/training\/public-250-%ce%bcg-dune-gonadoreline-et-10-de-gestation-en-plus","title":{"rendered":"250 \u03bcg D\u2019UNE GONADORELINE ET  10 % DE GESTATION EN PLUS"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\" style=\"--awb-content-alignment:justify;\"><p>REFERENCE : Lopez-Gatius F et Garcia-Ispierto I Treatment with an elevated dose of the GnRH analogue dephereline in the early luteal phase improves pregnancy rates in repeat-breeder dairy cows. Theriogenology 2020, <a href=\"https:\/\/doi.org\/10.1016\/j.theriogenology.2020.06.011\">doi.org\/10.1016\/j.theriogenology.2020.06.011<\/a><\/p>\n<h4><span style=\"color: #2eac80;\">BACKGROUND<\/span><\/h4>\n<p>Je suis certain que le traitement hormonal d\u2019une vache infertile continue de vous poser probl\u00e8me. Vous en avez trait\u00e9 au moyen de la GnRH lors de l\u2019ins\u00e9mination artificielle. Sans doute avez-vous observ\u00e9 une augmentation du % de gestation (22,5 % selon une m\u00e9ta-analyse r\u00e9alis\u00e9e \u00e0 partir de 27 publications (10.029 vaches infertiles). Vous avez ce faisant sans doute contribuer \u00e0 renforcer la lib\u00e9ration de la LH et assurer une meilleure ovulation et un d\u00e9veloppement plus optimal du corps jaune. Une alternative existe. Elle consiste classiquement en l\u2019injection d\u2019une GnRH plus de 10 jours apr\u00e8s l\u2019ins\u00e9mination.<\/p>\n<h4><span style=\"color: #2eac80;\">MATERIEL ET METHODES<\/span><\/h4>\n<p>Les auteurs de l\u2019\u00e9tude ont voulu tester les effets d\u2019une injection IM 5, 6 ou 7 jours apr\u00e8s la 3<sup>\u00e8me<\/sup> ins\u00e9mination d\u2019une dose de 100\u202f\u03bcg ou de 250 \u03bcg de dephereline (gonadorelin acetate\u00a0: GnRH de synth\u00e8se dans laquelle la glycine a \u00e9t\u00e9 remplac\u00e9e en position 6 par la d-phenylalanine\u00a0: 6-D-Phe\u00a0; Gonavet Veyx). Pour ce faire, ils ont dans un troupeau s\u00e9lectionn\u00e9 810 vaches laiti\u00e8res de race Holstein traites trois fois par jour (production annuelle de 11.840 kg) dont la production moyenne au moment du traitement, le stade du postpartum,\u00a0 la valeur du THI, le nombre d\u2019ins\u00e9mination moyen et le nombre de lactation moyen \u00e9taient respectivement de 40.9\u202f\u00b1\u202f9.0\u202fkg (20 \u00e0 71), 153\u202f\u00b1\u202f77.4 j (50 \u00e0 460), 59.7\u202f\u00b1\u202f12.4 (37 \u00e0 86), 3.8\u202f\u00b1\u202f2.7 (1 \u00e0 to 16) et 2.6\u202f\u00b1\u202f1.8 lactations (1 \u00e0 9).<\/p>\n<p>Les chaleurs furent d\u00e9tect\u00e9es au moyen d\u2019un podom\u00e8tre mais confirm\u00e9es par palpation manuelle. Un examen \u00e9chographique fut r\u00e9alis\u00e9 28 \u00e0 34 jours apr\u00e8s l\u2019ins\u00e9mination pour confirmer la gestation et d\u00e9terminer le nombre d\u2019embryons et de corps jaunes. Toute vache pr\u00e9sentant une pathologie telle que boiterie, infection ut\u00e9rine, pathologie digestive ou mammite fut exclue de l\u2019\u00e9tude.<\/p>\n<h4><span style=\"color: #2eac80;\">LEURS OBSERVATIONS<\/span><\/h4>\n<p>33,2 % (n=269) des vaches de l\u2019\u00e9tude (dont celles non trait\u00e9es) sont devenues gestantes. Un corps jaune accessoire fut d\u00e9tect\u00e9 chez 44,6 % d\u2019entre elles. 22,3 % des vaches gestantes avaient deux embryons. 11,9 % des vaches confirm\u00e9es gestantes pr\u00e9sent\u00e8rent une mortalit\u00e9 embryonnaire. Le jour du traitement (5, 6, 7) n\u2019a eu aucun effet significatif (36,9 %, 37,4 % et 34,3%).<\/p>\n<p>Les % de gestation chez les vaches t\u00e9moins, trait\u00e9es avec 100\u202f\u03bcg ou de 250 \u03bcg de dephereline furent respectivement de 28,6%, 31,9% et de 39,1%.<\/p>\n<p>L\u2019injection de 100\u202f\u03bcg ou de 250 \u03bcg de dephereline multiplie par 3 le % de vaches pr\u00e9sentant un corps jaune accessoire.<\/p>\n<p>Le THI, le NL, la production laiti\u00e8re, le technicien responsable de l\u2019ins\u00e9mination, le taureau, le nombre de jours de lactation\u00a0 n\u2019ont eu aucun effet significatif.<\/p>\n<p>DISCUSSION<\/p>\n<p>Cette \u00e9tude confirme indirectement l\u2019impact favorable d\u2019une augmentation de la progest\u00e9rone aussi rapide et \u00e9lev\u00e9e que possible dans les jours qui suivent l\u2019ins\u00e9mination. L\u2019effet positif de cet apport a \u00e9t\u00e9 d\u00e9montr\u00e9 et valid\u00e9 par la mise en place durant 7 jours d\u2019un CIDR 3 \u00e0 7 jours apr\u00e8s l\u2019ins\u00e9mination. Il s\u2019observe \u00e9galement apr\u00e8s l\u2019injection de 2500 UI avant ou apr\u00e8s le 5<sup>\u00e8me<\/sup> jour suivant l\u2019ins\u00e9mination.<\/p>\n<p>Ces traitements hormonaux ne devraient \u00eatre recommand\u00e9s que si le % de gestation est inf\u00e9rieur \u00e0 45%.<\/p>\n<p>Le % de mortalit\u00e9 embryonnaire plus \u00e9lev\u00e9 (13,2% et 12,8% vs 9,1%) vient cependant temp\u00e9rer le b\u00e9n\u00e9fice d\u2019un tel traitement.<\/p>\n<\/div><div class=\"fusion-image-element \" style=\"text-align:center;--awb-margin-top:30px;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"1040\" height=\"720\" title=\"Lopez-Gatius 2020 GnRH RB J5 6 7\" src=\"https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2023\/02\/Lopez-Gatius-2020-GnRH-RB-J5-6-7.jpg\" data-orig-src=\"https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2023\/02\/Lopez-Gatius-2020-GnRH-RB-J5-6-7.jpg\" alt class=\"lazyload img-responsive wp-image-1466\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271040%27%20height%3D%27720%27%20viewBox%3D%270%200%201040%20720%27%3E%3Crect%20width%3D%271040%27%20height%3D%27720%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2023\/02\/Lopez-Gatius-2020-GnRH-RB-J5-6-7-200x138.jpg 200w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2023\/02\/Lopez-Gatius-2020-GnRH-RB-J5-6-7-400x277.jpg 400w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2023\/02\/Lopez-Gatius-2020-GnRH-RB-J5-6-7-600x415.jpg 600w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2023\/02\/Lopez-Gatius-2020-GnRH-RB-J5-6-7-800x554.jpg 800w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2023\/02\/Lopez-Gatius-2020-GnRH-RB-J5-6-7.jpg 1040w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 640px) 100vw, 1040px\" \/><\/span><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":16,"featured_media":1412,"template":"","keyword":[],"theme":[59],"class_list":["post-1409","training","type-training","status-publish","has-post-thumbnail","hentry","theme-reproduction-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/training\/1409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/training"}],"about":[{"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/types\/training"}],"author":[{"embeddable":true,"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/users\/16"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/media\/1412"}],"wp:attachment":[{"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/media?parent=1409"}],"wp:term":[{"taxonomy":"keyword","embeddable":true,"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/keyword?post=1409"},{"taxonomy":"theme","embeddable":true,"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/theme?post=1409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}