{"id":2838,"date":"2024-03-24T08:30:18","date_gmt":"2024-03-24T07:30:18","guid":{"rendered":"https:\/\/www.rumexperts.vet\/?post_type=training&#038;p=2838"},"modified":"2024-03-24T08:30:32","modified_gmt":"2024-03-24T07:30:32","slug":"de-leffet-dun-ains-chez-des-receveuses-de-race-a-viande-en-cas-dendometrite-subclinique","status":"publish","type":"training","link":"https:\/\/www.rumexperts.vet\/en\/training\/de-leffet-dun-ains-chez-des-receveuses-de-race-a-viande-en-cas-dendometrite-subclinique","title":{"rendered":"De l&#8217;effet d&#8217;un AINS chez des receveuses de race \u00e0 viande en cas d&#8217;endom\u00e9trite subclinique"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>REFERENCE:\u00a0Barnes M. et al. Effect of subclinical endometritis and flunixin meglumine administration on pregnancy in embryo recipient beef cows. Theriogenology 201 (2023) 76-82.\u00a0 <a href=\"https:\/\/doi.org\/10.1016\/j.theriogenology.2023.02.020\">https:\/\/doi.org\/10.1016\/j.theriogenology.2023.02.020<\/a><\/p>\n<p>La flunixine meglumine, un AINS, \u00a0a la capacit\u00e9 d\u2019inhiber de mani\u00e8re non sp\u00e9cifique les cyclooxygenases 1 et 2, enzymes responsables de la synth\u00e8se de la PGF2\u03b1 au niveau endom\u00e9trial en r\u00e9ponse \u00e0 un \u00e9tat inflammatoire dont par exemple l\u2019endom\u00e9trite subclinique (ESC). Il en r\u00e9sulte une r\u00e9duction de la lut\u00e9olyse et donc du risque de mortalit\u00e9 embryonnaire pr\u00e9coce (MEP). Ainsi chez la g\u00e9nisse laiti\u00e8re, au seuil \u2265 1% de PMN, la pr\u00e9valence des endom\u00e9trites subcliniques serait au moment de l\u2019ins\u00e9mination \u00e9gale \u00e0 27,8 %. Sa pr\u00e9sence se traduit par une r\u00e9duction du % de gestation (32,7 vs 47 %) (Pascottini et al. 2016). De m\u00eame, en cas d\u2019endom\u00e9trite subclinique (\u2265 1% de PMN ) au moment de l\u2019ins\u00e9mination de vaches superovul\u00e9es, le nombre moyen d\u2019embryons r\u00e9colt\u00e9s (6.9 vs 10,3) et le nombre moyen d\u2019embryons transf\u00e9rables (3.7 vs 6.8) se trouve diminu\u00e9 (Drillich et al. 2012).<\/p>\n<p>LEUR QUESTION<\/p>\n<p>L\u2019injection IM au moment du transfert d\u2019un embryon de 500 mg de flunixine meglumine augmente-t-elle le % de gestation\u00a0?\u00a0 Le protocole exp\u00e9rimental est pr\u00e9sent\u00e9 dans la figure associ\u00e9e.<\/p>\n<p>LEURS REPONSES<\/p>\n<ul>\n<li>Une injection de FM augmente mais non significativement le % de gestation\u00a0: 55 vs 52.7 %. Cette augmentation est cependant significative en cas d\u2019ESC\u00a0: 53.4 vs 39.4 %.<\/li>\n<li>Les facteurs d\u2019influence \u00e9tudi\u00e9s n\u2019influencent pas significativement le % de gestation.<\/li>\n<li>La pr\u00e9sence d\u2019une ESC au seuil de \u2265 1% r\u00e9duit significativement le % de gestation\u00a0: 46 vs 55.9 %.<\/li>\n<\/ul>\n<p>UN PEU DE DISCUSSION<\/p>\n<p>Cette \u00e9tude confirme l\u2019effet n\u00e9gatif d\u2019une ESC (seuil \u2265 1% de PMN) sur la fertilit\u00e9.<\/p>\n<p>L\u2019\u00e9tat inflammatoire accompagnant une ESC se traduit par une expression accrue des g\u00e8nes responsables de la synth\u00e8se des cytokines et interleukines et donc de PGF2\u03b1. Il en r\u00e9sulte une diminution de la progest\u00e9rone et un risque accru de MEP. Par ailleurs, tout \u00e9tat de stress (stress thermique, nervosit\u00e9, nutrition\u2026) s\u2019accompagne d\u2019une augmentation du cortisol responsabe d\u2019une diminution de la GnRH et de la LH, hormone r\u00e9gulatrice de la synth\u00e8se de progest\u00e9rone.<\/p>\n<p>Une augmentation des PMN et de leur activit\u00e9 phagocytaire est classiquement observ\u00e9e durant les phases prooestrale et oestrale du cycle. Leur recrutement est \u00e9galement observ\u00e9 en d\u00e9but de gestation. Leurs effets pro ou antiinflammatoires d\u00e9pendraient de leur densit\u00e9.<\/p>\n<p>La s\u00e9lection des receveuses ne s\u2019improvise pas. Cette \u00e9tude confirme l\u2019int\u00e9r\u00eat potentiel d\u2019une d\u00e9tection des endom\u00e9trites subcliniques et le cas \u00e9ch\u00e9ant d\u2019une injection de flunixine meglumine.<\/p>\n<\/div><div class=\"fusion-image-element \" style=\"--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"1900\" height=\"1062\" title=\"Barnes 2023 AINS et transfert embryon et endometrite\" src=\"https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2024\/03\/Barnes-2023-AINS-et-transfert-embryon-et-endometrite-scaled.jpg\" data-orig-src=\"https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2024\/03\/Barnes-2023-AINS-et-transfert-embryon-et-endometrite-scaled.jpg\" alt class=\"lazyload img-responsive wp-image-2840\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271900%27%20height%3D%271062%27%20viewBox%3D%270%200%201900%201062%27%3E%3Crect%20width%3D%271900%27%20height%3D%271062%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2024\/03\/Barnes-2023-AINS-et-transfert-embryon-et-endometrite-200x112.jpg 200w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2024\/03\/Barnes-2023-AINS-et-transfert-embryon-et-endometrite-400x224.jpg 400w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2024\/03\/Barnes-2023-AINS-et-transfert-embryon-et-endometrite-600x335.jpg 600w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2024\/03\/Barnes-2023-AINS-et-transfert-embryon-et-endometrite-800x447.jpg 800w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2024\/03\/Barnes-2023-AINS-et-transfert-embryon-et-endometrite-1200x671.jpg 1200w, https:\/\/www.rumexperts.vet\/wp-content\/uploads\/2024\/03\/Barnes-2023-AINS-et-transfert-embryon-et-endometrite-scaled.jpg 1900w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 640px) 100vw, 1200px\" \/><\/span><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":20,"featured_media":2839,"template":"","keyword":[],"theme":[59],"class_list":["post-2838","training","type-training","status-publish","has-post-thumbnail","hentry","theme-reproduction-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/training\/2838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/training"}],"about":[{"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/types\/training"}],"author":[{"embeddable":true,"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/users\/20"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/media\/2839"}],"wp:attachment":[{"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/media?parent=2838"}],"wp:term":[{"taxonomy":"keyword","embeddable":true,"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/keyword?post=2838"},{"taxonomy":"theme","embeddable":true,"href":"https:\/\/www.rumexperts.vet\/en\/wp-json\/wp\/v2\/theme?post=2838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}